Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids | Zendy

Xiaohong Pan | Zendy; Thomas D. Bannister | Zendy

Open Access

Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids

Author(s) -

Xiaohong Pan,

Thomas D. Bannister

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol5029783

Subject(s) - chemistry , indole test , annulation , combinatorial chemistry , biological activity , scope (computer science) , coupling reaction , organic chemistry , catalysis , biochemistry , in vitro , computer science , programming language

A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties.

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