Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp. | Zendy

Peng Fu | Zendy; Matthew Jamison | Zendy; Scott La | Zendy; John B. MacMillan | Zendy

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Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.

Author(s) -

Peng Fu,

Matthew Jamison,

Scott La,

John B. MacMillan

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol502731p

Subject(s) - chemistry , strain (injury) , mutant , stereochemistry , amide , streptomyces , tryptophan , biochemistry , gene , amino acid , bacteria , genetics , biology , anatomy

Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

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