Open AccessA Universal Isocyanide for Diverse Heterocycle Syntheses
Author(s) -
Pravin Patil,
Kareem Khoury,
Eberhardt Herdtweck,
Alexander Dömlingꝉ
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol5024882
Subject(s) - isocyanide , tetrazole , chemistry , ugi reaction , combinatorial chemistry , organic chemistry
Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.
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