Cobalt-Catalyzed Direct Carbonylation of Aminoquinoline Benzamides | Zendy

Liene Grigorjeva | Zendy; Olafs Daugulis | Zendy

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Cobalt-Catalyzed Direct Carbonylation of Aminoquinoline Benzamides

Author(s) -

Liene Grigorjeva,

Olafs Daugulis

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol502007t

Subject(s) - chemistry , phthalimides , carbonylation , catalysis , nitro , ether , carbon monoxide , halogen , cobalt , organic chemistry , solvent , benzoic acid , combinatorial chemistry , alkyl , phthalimide

A method for direct carbonylation of aminoquinoline benzamides has been developed. Reactions proceed at room temperature in trifluoroethanol solvent, use oxygen from air as an oxidant, and require Mn(OAc)3 as a cocatalyst. Benzoic and acrylic acid derivatives can be carbonylated by carbon monoxide affording imides in good yields. Halogen, nitro, ether, cyano, and ester functional groups are tolerated. The directing group can be removed under mild conditions affording phthalimides.

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