Open AccessThe Redox-Mannich Reaction
Author(s) -
Weijie Chen,
Daniel Seidel
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol501365j
Subject(s) - chemistry , mannich reaction , redox , isomerization , benzoic acid , combinatorial chemistry , ring (chemistry) , reaction conditions , organic chemistry , component (thermodynamics) , catalysis , physics , thermodynamics
A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.
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