Palladium-Catalyzed α-Arylation of Benzylic Phosphonates | Zendy

Sonia Montel | Zendy; Ludovic Raffier | Zendy; Yu-Ying He | Zendy; Patrick J. Walsh | Zendy

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Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

Author(s) -

Sonia Montel,

Ludovic Raffier,

Yu-Ying He,

Patrick J. Walsh

Publication year - 2014

Publication title -

organic letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol5002413

Subject(s) - chemistry , phosphonate , catalysis , palladium , aryl , combinatorial chemistry , organic chemistry , transformation (genetics) , reaction conditions , medicinal chemistry , alkyl , biochemistry , gene

A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).

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