Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides | Zendy

Timothy K. Beng | Zendy; Sidney M. WilkersonHill | Zendy; Richmond Sarpong | Zendy

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Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides

Author(s) -

Timothy K. Beng,

Sidney M. WilkersonHill,

Richmond Sarpong

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol403671s

Subject(s) - chemistry , halo , coupling (piping) , nucleophile , palladium , combinatorial chemistry , coupling reaction , computational chemistry , organic chemistry , catalysis , physics , quantum mechanics , galaxy , mechanical engineering , engineering

The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.

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