Open AccessIron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation
Author(s) -
John J. Sirois,
Riley Davis,
Brenton DeBoef
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol403634b
Subject(s) - chemistry , catalysis , imine , surface modification , combinatorial chemistry , organic chemistry
The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.
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