Open AccessActivating Group Recycling in Action: A Rhodium-Catalyzed Carbothiolation Route to Substituted Isoquinolines
Author(s) -
Milan Arambasic,
Joel F. Hooper,
Michael C. Willis
Publication year - 2013
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol402650q
Subject(s) - rhodium , chemistry , catalysis , alkyne , aryl , sulfide , adduct , ketone , methyl ketone , group (periodic table) , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.
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