Open AccessWang Linker Free of Side Reactions
Author(s) -
Vida Castro,
Hortensia Rodrı́guez,
Fernando Alberício
Publication year - 2012
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol303367s
Subject(s) - linker , chemistry , solid phase synthesis , peptide , combinatorial chemistry , ring (chemistry) , click chemistry , phase (matter) , peptide synthesis , catalysis , copper , side chain , polymer chemistry , stereochemistry , organic chemistry , biochemistry , polymer , computer science , operating system
A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.
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