Structure and Biosynthesis of the Antibiotic Bottromycin D | Zendy

Yanpeng Hou | Zendy; Ma. Diarey B. Tianero | Zendy; Jason C. Kwan | Zendy; Thomas P. Wyche | Zendy; Cole Michel | Zendy; Gregory A. Ellis | Zendy; Emmanuel Vazquez-Rivera | Zendy; Doug R. Braun | Zendy; Warren E. Rose | Zendy; Eric W. Schmidt | Zendy; Tim S. Bugni | Zendy

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Structure and Biosynthesis of the Antibiotic Bottromycin D

Author(s) -

Yanpeng Hou,

Ma. Diarey B. Tianero,

Jason C. Kwan,

Thomas P. Wyche,

Cole Michel,

Gregory A. Ellis,

Emmanuel Vazquez-Rivera,

Doug R. Braun,

Warren E. Rose,

Eric W. Schmidt,

Tim S. Bugni

Publication year - 2012

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol3022758

Subject(s) - antibiotics , biosynthesis , chemistry , streptomyces , ribosomal rna , computational biology , genome , biochemistry , bacteria , gene , biology , genetics

Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway.

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