Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones | Zendy

Sebastian T. Le Quement | Zendy; Thomas Flagstad | Zendy; Remi J. T. Mikkelsen | Zendy; Mette R. Hansen | Zendy; Michael Givskov | Zendy; Thomas E. Nielsen | Zendy

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Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones

Author(s) -

Sebastian T. Le Quement,

Thomas Flagstad,

Remi J. T. Mikkelsen,

Mette R. Hansen,

Michael Givskov,

Thomas E. Nielsen

Publication year - 2012

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol203280b

Subject(s) - chemistry , triphosgene , component (thermodynamics) , combinatorial chemistry , scope (computer science) , substrate (aquarium) , coupling reaction , ring (chemistry) , coupling (piping) , reaction conditions , organic chemistry , catalysis , computer science , programming language , mechanical engineering , physics , oceanography , geology , engineering , thermodynamics , phosgene

An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.

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