Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264 | Zendy

Gavin Carr | Zendy; Mohammad R. Seyedsayamdost | Zendy; Josephine R. Chandler | Zendy; E. Peter Greenberg | Zendy; Jon Clardy | Zendy

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Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264

Author(s) -

Gavin Carr,

Mohammad R. Seyedsayamdost,

Josephine R. Chandler,

E. Peter Greenberg,

Jon Clardy

Publication year - 2011

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol200922s

Subject(s) - biosynthesis , mutant , burkholderia , chemistry , enzyme , computational biology , gene cluster , biochemistry , stereochemistry , genetics , bacteria , biology , gene

A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.

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