Cytotoxic C35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica | Zendy

ChengChi Chen | Zendy; JyhHorng Wu | Zendy; NingSun Yang | Zendy; JangYang Chang | Zendy; ChingChuan Kuo | Zendy; ShengYang Wang | Zendy; YuehHsiung Kuo | Zendy

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Cytotoxic C₃₅ Terpenoid Cryptotrione from the Bark of Cryptomeria japonica

Author(s) -

ChengChi Chen,

JyhHorng Wu,

NingSun Yang,

JangYang Chang,

ChingChuan Kuo,

ShengYang Wang,

YuehHsiung Kuo

Publication year - 2010

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol1009027

Subject(s) - cryptomeria , diterpene , abietane , terpenoid , chemistry , bark (sound) , japonica , sesquiterpene , stereochemistry , carbon skeleton , terpene , bicyclic molecule , botany , biology , ecology

A novel C(35)-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC(50) value of 6.44 +/- 2.23 microM.

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