Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-Based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety | Zendy

Chen-Yu Liu | Zendy; ChihWei Guo | Zendy; YiFan Chang | Zendy; Jen-Tsung Wang | Zendy; HaoWei Shih | Zendy; YuFang Hsu | Zendy; ChiaWei Chen | Zendy; Shao-Kang Chen | Zendy; Yen-Chih Wang | Zendy; Ting-Jen Rachel Cheng | Zendy; Che Ma | Zendy; ChiHuey Wong | Zendy; JimMin Fang | Zendy; WeiChieh Cheng | Zendy

Open Access

Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-Based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety

Author(s) -

Chen-Yu Liu,

ChihWei Guo,

YiFan Chang,

Jen-Tsung Wang,

HaoWei Shih,

YuFang Hsu,

ChiaWei Chen,

Shao-Kang Chen,

Yen-Chih Wang,

Ting-Jen Rachel Cheng,

Che Ma,

ChiHuey Wong,

JimMin Fang,

WeiChieh Cheng

Publication year - 2010

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol100338v

Subject(s) - chemistry , substrate (aquarium) , fluorescence , fluorophore , moiety , biochemistry , peptide , molecule , stereochemistry , combinatorial chemistry , biophysics , organic chemistry , oceanography , physics , quantum mechanics , biology , geology

The preparation of a novel fluorescent lipid II-based substrate for transglycosylases (TGases) is described. This substrate has characteristic structural features including a shorter lipid chain, a fluorophore tag at the end of the lipid chain rather than on the peptide chain, and no labeling with a radioactive atom. This fluorescent substrate is readily utilized in TGase activity assays to characterize TGases and also to evaluate the activities of TGase inhibitors.

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