Open AccessHighly Enantioselective Synthesis of β-Amino Alcohols
Author(s) -
ThomasXavier Métro,
Jérôme Appenzeller,
Domingo Gomez Pardo,
Janine Cossy
Publication year - 2006
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol061133d
Subject(s) - enantioselective synthesis , chemistry , organic chemistry , combinatorial chemistry , stereochemistry , catalysis
[reaction: see text] N,N-Dialkyl-beta-amino alcohols derived from alpha-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.
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