Open AccessProrocentin, a New Polyketide from the Marine Dinoflagellate Prorocentrum lima
Author(s) -
ChungKuang Lu,
Hongg Chou,
ChingKuo Lee,
TzongHuei Lee
Publication year - 2005
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol051300u
Subject(s) - dinoflagellate , chemistry , polyketide , polyene , stereochemistry , marine toxin , epoxide , ring (chemistry) , okadaic acid , toxin , botany , organic chemistry , biochemistry , catalysis , biosynthesis , biology , enzyme , phosphatase
Prorocentin (1), isolated from an okadaic acid-producing organism, Prorocentrum lima, possessed all-trans trienes, an epoxide, as well as the 6/6/6-trans-fused/spiro-linked polyether ring moieties. The unique structure supports the proposed cyclization mechanism, polyene formation, epoxidation, and cyclization, of marine polyether toxins. The relative stereostructure was determined on the basis of spectral data. [structure: see text]
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