Kumada−Corriu Reactions of Alkyl Halides with Alkynyl Nucleophiles | Zendy

LianMing Yang | Zendy; LiFu Huang | Zendy; TienYau Luh | Zendy

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Kumada−Corriu Reactions of Alkyl Halides with Alkynyl Nucleophiles

Author(s) -

LianMing Yang,

LiFu Huang,

TienYau Luh

Publication year - 2004

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol049686g

Subject(s) - chemistry , nucleophile , alkyl , reagent , halide , ligand (biochemistry) , reductive elimination , medicinal chemistry , coupling reaction , combinatorial chemistry , catalysis , organic chemistry , biochemistry , receptor

[reaction: see text] Pd(2)(dba)(3)-Ph(3)P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish C(sp)-C(sp)3 bond formation. Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph(3)P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.

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