Synthesis of Saponins Using Partially Protected Glycosyl Donors | Zendy

Yuguo Du | Zendy; Guofeng Gu | Zendy; Guohua Wei | Zendy; Yuxia Hua | Zendy; Robert J. Linhardt | Zendy

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Synthesis of Saponins Using Partially Protected Glycosyl Donors

Author(s) -

Yuguo Du,

Guofeng Gu,

Guohua Wei,

Yuxia Hua,

Robert J. Linhardt

Publication year - 2003

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol035353s

Subject(s) - glycosyl , chemistry , glycosylation , yield (engineering) , glycoside , saponin , alkyl , glycosyl donor , stereochemistry , oligosaccharide , combinatorial chemistry , organic chemistry , biochemistry , medicine , materials science , alternative medicine , pathology , metallurgy

[reaction: see text] A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.

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