Design and Synthesis of Activity Probes for Glycosidases | Zendy

Charng-Sheng Tsai | Zendy; YawKuen Li | Zendy; LeeChiang Lo | Zendy

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Design and Synthesis of Activity Probes for Glycosidases

Author(s) -

Charng-Sheng Tsai,

YawKuen Li,

LeeChiang Lo

Publication year - 2002

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol0265315

Subject(s) - chemistry , linker , combinatorial chemistry , surface modification , flexibility (engineering) , glycoside hydrolase , enzyme , nanotechnology , biochemistry , computer science , statistics , materials science , mathematics , operating system

[structure: see text] A new synthetic route was developed for the preparation of activity probe 1 for beta-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations.

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