Ceramide and Cerebrosides from the Octocoral Sarcophyton ehrenbergi | Zendy

ShiYie Cheng | Zendy; ZhiHong Wen | Zendy; ShuFen Chiou | Zendy; Chung-Wei Tsai | Zendy; ShangKwei Wang | Zendy; ChiHsin Hsu | Zendy; ChangFeng Dai | Zendy; Michael Y. Chiang | Zendy; WeiHsien Wang | Zendy; ChangYih Duh | Zendy

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Ceramide and Cerebrosides from the Octocoral Sarcophyton ehrenbergi

Author(s) -

ShiYie Cheng,

ZhiHong Wen,

ShuFen Chiou,

Chung-Wei Tsai,

ShangKwei Wang,

ChiHsin Hsu,

ChangFeng Dai,

Michael Y. Chiang,

WeiHsien Wang,

ChangYih Duh

Publication year - 2008

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np800362g

Subject(s) - ceramide , biology , cerebroside , moiety , antimicrobial , stereochemistry , chemistry , biochemistry , microbiology and biotechnology , apoptosis

Chemical investigation of the octocoral Sarcophyton ehrenbergi, collected at the Dongsha Islands, Taiwan, has led to the isolation of a known ceramide (1) and two new cerebrosides, sarcoehrenosides A (2) and B (4), along with three known cerebrosides (3, 5, and 6). The structures of the new compounds were established by spectroscopic and chemical methods. Sarcoehrenoside A (2) differs from previously known marine cerebrosides in that it possesses a rare alpha-glucose moiety. Compounds 1-6 were evaluated for antimicrobial activity against a small panel of bacteria and for anti-inflammatory activity using RAW 264.7 macrophages.

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