Mycophenolic Derivatives from Eupenicillium parvum | Zendy

Eman S. Habib | Zendy; Francisco León | Zendy; John D. Bauer | Zendy; Robert A. Hill | Zendy; Paulo Carvalho | Zendy; Horace G. Cutler | Zendy; Stephen J. Cutler | Zendy

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Mycophenolic Derivatives from Eupenicillium parvum

Author(s) -

Eman S. Habib,

Francisco León,

John D. Bauer,

Robert A. Hill,

Paulo Carvalho,

Horace G. Cutler,

Stephen J. Cutler

Publication year - 2008

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np8003497

Subject(s) - heteronuclear molecule , derivatization , absolute configuration , stereochemistry , chemistry , nuclear magnetic resonance spectroscopy , mass spectrometry , chromatography

A new compound, euparvic acid (1, C(14)H(16)O(6)), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1 was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5 was determined via MPA ester derivatization.

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