Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana | Zendy

Pei-Hsuan Chuang | Zendy; PeiWen Hsieh | Zendy; Yuliang Yang | Zendy; Kuo-Feng Hua | Zendy; FangRong Chang | Zendy; Jentaie Shiea | Zendy; Shih-Hsiung Wu | Zendy; YangChang Wu | Zendy

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Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana

Author(s) -

Pei-Hsuan Chuang,

PeiWen Hsieh,

Yuliang Yang,

Kuo-Feng Hua,

FangRong Chang,

Jentaie Shiea,

Shih-Hsiung Wu,

YangChang Wu

Publication year - 2008

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np8001282

Subject(s) - pharmacognosy , annona , stereochemistry , in vitro , chemistry , biological activity , methanol , two dimensional nuclear magnetic resonance spectroscopy , annonaceae , traditional medicine , biology , botany , biochemistry , organic chemistry , medicine

Four new cyclopeptides, cyclomontanins A-D (1- 4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

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