Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1 | Zendy

Yixi Liu | Zendy; Kelly A. Young | Zendy; Liva Harinantenaina | Zendy; Peggy J. Brodie | Zendy; Jessica D. Wiley | Zendy; María B. Cassera | Zendy; Martin W. Callmander | Zendy; R. Rakotondrajaona | Zendy; Etienne Rakotobe | Zendy; Vincent E. Rasamison | Zendy; Karen TenDyke | Zendy; Yongchun Shen | Zendy; David G. I. Kingston | Zendy

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Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1

Author(s) -

Yixi Liu,

Kelly A. Young,

Liva Harinantenaina,

Peggy J. Brodie,

Jessica D. Wiley,

María B. Cassera,

Martin W. Callmander,

R. Rakotondrajaona,

Etienne Rakotobe,

Vincent E. Rasamison,

Karen TenDyke,

Yongchun Shen,

David G. I. Kingston

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np501020m

Subject(s) - ic50 , stereochemistry , cell culture , chemistry , traditional medicine , biology , medicine , biochemistry , in vitro , genetics

The two new lignans 3α-O-(β-D-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(β-D-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (±)-β-apopicropodophyllin (4), (-)-desoxypodophyllotoxin (5), (-)-yatein (6), and β-peltatin-5-O-β-D-glucopyranoside (7). The structures of all compounds were characterized by spectroscopic techniques. Compounds 1, 4, and 5 showed potent antiproliferative activities against the A2780 ovarian cancer cell line, with IC50 values of 33.0 ± 3.6, 63.1 ± 6.7, and 230 ± 1 nM, respectively. Compounds 2 and 7 showed only modest A2780 activities, with IC50 values of 2.1 ± 0.3 and 4.9 ± 0.1 μM, respectively, while compounds 3 and 6 had IC50 values of >10 μM. Compound 1 also had potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC50 value of 20.5 nM, and compound 4 exhibited modest antiproliferative activity against the A2058 human caucasian metastatic melanoma and MES-SA human uterine sarcoma cell lines, with IC50 values of 4.6 and 4.0 μM, respectively.

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