Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora | Zendy

Peng Fu | Zendy; John B. MacMillan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora

Author(s) -

Peng Fu,

John B. MacMillan

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np500929z

Subject(s) - thiazole , moiety , stereochemistry , cancer cell lines , natural product , cytotoxicity , chemistry , thiazine , ic50 , combinatorial chemistry , organic chemistry , biology , cancer cell , in vitro , biochemistry , cancer , genetics

Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research