Neopetrocyclamines A and B, Polycyclic Diamine Alkaloids from the Sponge Neopetrosia cf exigua | Zendy

Zhibin Liang | Zendy; Florian J. Sulzmaier | Zendy; Wesley Y. Yoshida | Zendy; Michelle Kelly | Zendy; Joe W. Ramos | Zendy; Philip G. Williams | Zendy

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Neopetrocyclamines A and B, Polycyclic Diamine Alkaloids from the Sponge Neopetrosia cf exigua

Author(s) -

Zhibin Liang,

Florian J. Sulzmaier,

Wesley Y. Yoshida,

Michelle Kelly,

Joe W. Ramos,

Philip G. Williams

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np500759r

Subject(s) - moiety , stereochemistry , exigua , sponge , chemistry , ring (chemistry) , formamidinium , biology , organic chemistry , spodoptera , botany , biochemistry , perovskite (structure) , gene , recombinant dna

Two new polycyclic alkaloids, neopetrocyclamines A and B (1 and 2), along with the known metabolites papuamine (3) and haliclonadiamine (4), were isolated from the Indonesian sponge Neopetrosia cf exigua. Neopetrocyclamine A contains a formamidinium moiety, a rare functional group. While these compounds share the same basic biosynthetic building blocks, the size of the ring system differs in 1 and 2 because of the formamidinium moiety. Biological evaluations of 1-4 revealed that papuamine is cytotoxic against glioblastoma SF-295 cells (GI50 = 0.8 μM).

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