Denhaminols A–H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides | Zendy

Claire Levrier | Zendy; Martin C. Sadowski | Zendy; Colleen C. Nelson | Zendy; Peter C. Healy | Zendy; Rohan A. Davis | Zendy

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Denhaminols A–H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides

Author(s) -

Claire Levrier,

Martin C. Sadowski,

Colleen C. Nelson,

Peter C. Healy,

Rohan A. Davis

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np500740f

Subject(s) - lncap , rainforest , stereochemistry , chemistry , absolute configuration , cancer cell lines , botany , biology , prostate cancer , cancer cell , cancer , genetics

Eight new dihydro-β-agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.

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