Antiproliferative Withanolides from Datura wrightii | Zendy

Huaping Zhang | Zendy; Joseph Bazzill | Zendy; Robert J. Gallagher | Zendy; Chitra Subramanian | Zendy; Patrick T. Grogan | Zendy; Victor W. Day | Zendy; Kelly Kindscher | Zendy; Mark S. Cohen | Zendy; Barbara N. Timmermann | Zendy

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Antiproliferative Withanolides from Datura wrightii

Author(s) -

Huaping Zhang,

Joseph Bazzill,

Robert J. Gallagher,

Chitra Subramanian,

Patrick T. Grogan,

Victor W. Day,

Kelly Kindscher,

Mark S. Cohen,

Barbara N. Timmermann

Publication year - 2012

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np300766p

Subject(s) - solanaceae , datura , biology , pharmacognosy , botany , traditional medicine , withanolide , medicine , biological activity , biochemistry , in vitro , alternative medicine , pathology , gene , withania somnifera

A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 μM.

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