Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. | Zendy

Gavin Carr | Zendy; Emily R. Derbyshire | Zendy; Eric J. Caldera | Zendy; Cameron R. Currie | Zendy; Jon Clardy | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

Author(s) -

Gavin Carr,

Emily R. Derbyshire,

Eric J. Caldera,

Cameron R. Currie,

Jon Clardy

Publication year - 2012

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np300380t

Subject(s) - antibiotics , fungus , biology , bacillus subtilis , microbiology and biotechnology , cytotoxicity , plasmodium berghei , bacteria , biochemistry , malaria , botany , in vitro , genetics , immunology

Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research