Ianthelliformisamines A–C, Antibacterial Bromotyrosine-Derived Metabolites from the Marine Sponge Suberea ianthelliformis | Zendy

Min Xu | Zendy; Rohan A. Davis | Zendy; Yunjiang Feng | Zendy; Melissa L. Sykes | Zendy; Todd Shelper | Zendy; Vicky M. Avery | Zendy; David Camp | Zendy; Ronald J. Quinn | Zendy

Open Access

Ianthelliformisamines A–C, Antibacterial Bromotyrosine-Derived Metabolites from the Marine Sponge Suberea ianthelliformis

Author(s) -

Min Xu,

Rohan A. Davis,

Yunjiang Feng,

Melissa L. Sykes,

Todd Shelper,

Vicky M. Avery,

David Camp,

Ronald J. Quinn

Publication year - 2012

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np300147d

Subject(s) - sponge , natural product , pseudomonas aeruginosa , stereochemistry , antibacterial activity , bacteria , strain (injury) , chemistry , minimum inhibitory concentration , microbiology and biotechnology , marine bacteriophage , in vitro , biology , biochemistry , botany , genetics , anatomy

A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-directed isolation of the CH(2)Cl(2)/CH(3)OH extract from S. ianthelliformis resulted in the purification of three new bromotyrosine-derived metabolites, ianthelliformisamines A-C (1-3), together with the known natural products aplysamine 1 (4) and araplysillin I (5). The structures of 1-3 were determined following analysis of 1D and 2D NMR and MS spectroscopic data. This is the first report of chemistry from the marine sponge S. ianthelliformis. Ianthelliformisamine A (1) showed inhibitory activity against the Gram-negative bacterium P. aeruginosa with an IC(50) value of 6.8 μM (MIC = 35 μM).

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