Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species | Zendy

Birgit Ohlendorf | Zendy; Dirk Schulz | Zendy; Arlette Erhard | Zendy; Kerstin Nagel | Zendy; Johannes F. Imhoff | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species

Author(s) -

Birgit Ohlendorf,

Dirk Schulz,

Arlette Erhard,

Kerstin Nagel,

Johannes F. Imhoff

Publication year - 2012

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np2009626

Subject(s) - streptomyces , natural product , acetylcholinesterase , streptomycetaceae , stereochemistry , strain (injury) , enzyme , acetylcholinesterase inhibitor , antibacterial activity , natural product research , actinomycetales , chemistry , biochemistry , biology , pharmacognosy , biological activity , bacteria , in vitro , genetics , anatomy

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research