Caelestines A−D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis | Zendy

Sheng Yin | Zendy; Glen M. Boyle | Zendy; Anthony R. Carroll | Zendy; Michael Kotiw | Zendy; John Dearnaley | Zendy; Ronald J. Quinn | Zendy; Rohan A. Davis | Zendy

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Caelestines A−D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis

Author(s) -

Sheng Yin,

Glen M. Boyle,

Anthony R. Carroll,

Michael Kotiw,

John Dearnaley,

Ronald J. Quinn,

Rohan A. Davis

Publication year - 2010

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np100329w

Subject(s) - chemistry , stereochemistry , cytotoxicity , organic chemistry , in vitro , biochemistry

Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.

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