Neuroprotective Diterpenes from the Fruiting Body of Antrodia camphorata | Zendy

ChengChi Chen | Zendy; YoungJi Shiao | Zendy; Ruei-Da Lin | Zendy; YiYuan Shao | Zendy; MinNan Lai | Zendy; ChunChing Lin | Zendy; LeanTeik Ng | Zendy; YuehHsiung Kuo | Zendy

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Neuroprotective Diterpenes from the Fruiting Body of Antrodia camphorata

Author(s) -

ChengChi Chen,

YoungJi Shiao,

Ruei-Da Lin,

YiYuan Shao,

MinNan Lai,

ChunChing Lin,

LeanTeik Ng,

YuehHsiung Kuo

Publication year - 2006

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np0581263

Subject(s) - neuroprotection , diterpene , biology , botany , chemistry , stereochemistry , pharmacology

Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.

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