Steroids and Sesquiterpenoids from the Soft Corals Dendronephthya gigantea and Lemnalia cervicorni | Zendy

ChangYih Duh | Zendy; Ali A. ElGamal | Zendy; Pei-Ying Song | Zendy; ShangKwei Wang | Zendy; ChangFeng Dai | Zendy

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Steroids and Sesquiterpenoids from the Soft Corals Dendronephthya gigantea and Lemnalia cervicorni

Author(s) -

ChangYih Duh,

Ali A. ElGamal,

Pei-Ying Song,

ShangKwei Wang,

ChangFeng Dai

Publication year - 2004

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np030550l

Subject(s) - coral , stereochemistry , methylene , steroid , chloride , cytotoxicity , cytotoxic t cell , in vitro , chemistry , biology , biochemistry , organic chemistry , ecology , hormone

One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-alpha-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

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