Open AccessFunctional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria
Author(s) -
Xiaoning Li,
Sandra Robinson,
Akash Gupta,
Krishnendu Saha,
Ziwen Jiang,
Daniel F. Moyano,
A Zaki Sahar,
Margaret A. Riley,
Vincent M. Rotello
Publication year - 2014
Publication title -
acs nano
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.554
H-Index - 382
eISSN - 1936-086X
pISSN - 1936-0851
DOI - 10.1021/nn5042625
Subject(s) - colloidal gold , antimicrobial , rational design , bacteria , pathogenic bacteria , nanoparticle , drug , nanotechnology , drug resistance , gram negative bacteria , combinatorial chemistry , materials science , chemistry , microbiology and biotechnology , escherichia coli , biology , pharmacology , biochemistry , genetics , gene
We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure-activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.
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