Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity | Zendy

Daniel F. Moyano | Zendy; Krishnendu Saha | Zendy; Gyan Prakash | Zendy; Bo Yan | Zendy; Hao Kong | Zendy; Mahdieh Yazdani | Zendy; Vincent M. Rotello | Zendy

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Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity

Author(s) -

Daniel F. Moyano,

Krishnendu Saha,

Gyan Prakash,

Bo Yan,

Hao Kong,

Mahdieh Yazdani,

Vincent M. Rotello

Publication year - 2014

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/nn5006478

Subject(s) - nanoparticle , nanotechnology , adsorption , corona (planetary geology) , protein adsorption , materials science , hemolysis , particle (ecology) , chemical engineering , chemistry , biophysics , organic chemistry , physics , oceanography , astrobiology , geology , venus , engineering , immunology , biology

A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.

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