Directed Self-Assembly of Lipid Nanotubes from Inverted Hexagonal Structures | Zendy

Kaori Sugihara | Zendy; Mohamed Chami | Zendy; Imre Derényi | Zendy; János Vörös | Zendy; Tomaso Zambelli | Zendy

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Directed Self-Assembly of Lipid Nanotubes from Inverted Hexagonal Structures

Author(s) -

Kaori Sugihara,

Mohamed Chami,

Imre Derényi,

János Vörös,

Tomaso Zambelli

Publication year - 2012

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/nn300557s

Subject(s) - materials science , lamellar structure , hexagonal crystal system , tube (container) , self assembly , phase (matter) , hexagonal phase , nanotechnology , lipid bilayer phase behavior , polyelectrolyte , microfluidics , crystallography , lipid bilayer , chemical engineering , chemistry , membrane , composite material , polymer , organic chemistry , biochemistry , engineering

Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.

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