A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO2 Core/Shell Nanocomposites | Zendy

YungKang Peng | Zendy; ChihWei Lai | Zendy; ChienLiang Liu | Zendy; HsiehChih Chen | Zendy; YiHsuan Hsiao | Zendy; Weiliang Liu | Zendy; KuoChun Tang | Zendy; Yün Chi | Zendy; JongKai Hsiao | Zendy; Kun-Eng Lim | Zendy; HungEn Liao | Zendy; JingJong Shyue | Zendy; PiTai Chou | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO₂ Core/Shell Nanocomposites

Author(s) -

YungKang Peng,

ChihWei Lai,

ChienLiang Liu,

HsiehChih Chen,

YiHsuan Hsiao,

Weiliang Liu,

KuoChun Tang,

Yün Chi,

JongKai Hsiao,

Kun-Eng Lim,

HungEn Liao,

JingJong Shyue,

PiTai Chou

Publication year - 2011

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/nn200928r

Subject(s) - materials science , nanocomposite , iridium , mesoporous silica , peg ratio , chemical engineering , nanocrystal , nanotechnology , mesoporous material , polyethylene glycol , nanoparticle , porosity , superparamagnetism , catalysis , composite material , chemistry , magnetization , organic chemistry , finance , engineering , economics , magnetic field , physics , quantum mechanics

Trifunctional uniform nanoparticles comprising a manganese nanocrystal core and a functionalized mesoporous silica shell (MnO@mSiO(2)(Ir)@PEG, where Ir is an emissive iridium complex and PEG is polyethylene glycol) have been strategically designed and synthesized. The T(1) signal can be optimized by forming hollow core (H-MnO@mSiO(2)(Ir)@PEG) via a novel and facile etching process, for which the mechanism has been discussed in detail. Systematic investigation on correlation for longitudinal relaxation (T(1)) versus core shapes and shell silica porosity of the nanocomposites (MnO, H-MnO, MnO@SiO(2), MnO@mSiO(2), H-MnO@mSiO(2)) has been carried out. The results show that the worm-like nanochannels in the mesoporous silica shell not only increase water permeability to the interior hollow manganese oxide core for T(1) signal but also enhance photodynamic therapy (PDT) efficacy by enabling the free diffusion of oxygen. Notably, the H-MnO@mSiO(2)(Ir)@PEG nanocomposite with promising r(1) relaxivity demonstrates its versatility, in which the magnetic core provides the capability for magnetic resonance imaging, while the simultaneous red phosphorescence and singlet oxygen generation from the Ir complex are capable of providing optical imaging and inducing apoptosis, respectively.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research