Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors | Zendy

Parag Katira | Zendy; Henry Hess | Zendy

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Two-Stage Capture Employing Active Transport Enables Sensitive and Fast Biosensors

Author(s) -

Parag Katira,

Henry Hess

Publication year - 2010

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl903468p

Subject(s) - analyte , biosensor , nanoscopic scale , nanotechnology , noise (video) , signal (programming language) , kinesin , mass transport , chemistry , materials science , microtubule , computer science , chromatography , physics , artificial intelligence , microbiology and biotechnology , image (mathematics) , biology , programming language , engineering physics

Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.

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