Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container | Zendy

Yonggang Ke | Zendy; Jaswinder Sharma | Zendy; Minghui Liu | Zendy; Kasper Jahn | Zendy; Yan Liu | Zendy; Hao Yan | Zendy

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Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

Author(s) -

Yonggang Ke,

Jaswinder Sharma,

Minghui Liu,

Kasper Jahn,

Yan Liu,

Hao Yan

Publication year - 2009

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl901165f

Subject(s) - tetrahedron , dna origami , pyramid (geometry) , transmission electron microscopy , volume (thermodynamics) , dna nanotechnology , dna , crystallography , nanotechnology , geometry , chemistry , physics , materials science , optics , mathematics , nanostructure , biochemistry , quantum mechanics

We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is approximately 54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 x 10(-23) and 1.5 x 10(-23) m(3), respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.

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