Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons | Zendy

Nicholas Stephanopoulos | Zendy; Ronit Freeman | Zendy; Hilary A. North | Zendy; Shantanu Sur | Zendy; Su Ji Jeong | Zendy; Faifan Tantakitti | Zendy; John A. Kessler | Zendy; Samuel I. Stupp | Zendy

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Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons

Author(s) -

Nicholas Stephanopoulos,

Ronit Freeman,

Hilary A. North,

Shantanu Sur,

Su Ji Jeong,

Faifan Tantakitti,

John A. Kessler,

Samuel I. Stupp

Publication year - 2014

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl504079q

Subject(s) - stem cell , peptide , neural stem cell , cellular differentiation , nanotechnology , microbiology and biotechnology , cell adhesion , neurosphere , dna , chemistry , nanostructure , cell , biophysics , biology , materials science , biochemistry , adult stem cell , gene

We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson-Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.

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