Multifunctional RNA Nanoparticles | Zendy

Kirill A. Afonin | Zendy; Mathias Viard | Zendy; Alexey Y. Koyfman | Zendy; Angélica N. Martins | Zendy; Wojciech K. Kasprzak | Zendy; Martin Panigaj | Zendy; Ravi A. Desai | Zendy; Arti Santhanam | Zendy; Wade W. Grabow | Zendy; Luc Jaeger | Zendy; Eliahu Heldman | Zendy; Jakob Reiser | Zendy; Wah Chiu | Zendy; Eric O. Freed | Zendy; Bruce A. Shapiro | Zendy

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Multifunctional RNA Nanoparticles

Author(s) -

Kirill A. Afonin,

Mathias Viard,

Alexey Y. Koyfman,

Angélica N. Martins,

Wojciech K. Kasprzak,

Martin Panigaj,

Ravi A. Desai,

Arti Santhanam,

Wade W. Grabow,

Luc Jaeger,

Eliahu Heldman,

Jakob Reiser,

Wah Chiu,

Eric O. Freed,

Bruce A. Shapiro

Publication year - 2014

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl502385k

Subject(s) - rna , nanotechnology , oligonucleotide , dna , aptamer , fluorescence , small interfering rna , ribozyme , chemistry , materials science , biology , gene , microbiology and biotechnology , physics , biochemistry , quantum mechanics

Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

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