Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission | Zendy

Yang Liu | Zendy; Rebecca Medda | Zendy; Zheng Liu | Zendy; Kornelia Galior | Zendy; Kevin Yehl | Zendy; Joachim P. Spatz | Zendy; Elisabetta Ada CavalcantiAdam | Zendy; Khalid Salaita | Zendy

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Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission

Author(s) -

Yang Liu,

Rebecca Medda,

Zheng Liu,

Kornelia Galior,

Kevin Yehl,

Joachim P. Spatz,

Elisabetta Ada CavalcantiAdam,

Khalid Salaita

Publication year - 2014

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl501912g

Subject(s) - nanoscopic scale , nanotechnology , mechanotransduction , nanolithography , integrin , nanoparticle , materials science , fluorescence microscope , fluorescence , biophysics , chemistry , receptor , microbiology and biotechnology , optics , biology , physics , biochemistry , medicine , alternative medicine , pathology , fabrication

Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering and its role in mechanotransduction pathways.

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