Open AccessPEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
Author(s) -
Jillian L. Perry,
Kevin Reuter,
Marc P. Kai,
Kevin P. Herlihy,
Stephen Jones,
J. Chris Luft,
Mary A. Napier,
James E. Bear,
Joseph M. DeSimone
Publication year - 2012
Publication title -
nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/nl302638g
Subject(s) - pegylation , biodistribution , nanoparticle , peg ratio , chemistry , biophysics , in vivo , nanotechnology , particle (ecology) , plasma protein binding , pharmacokinetics , materials science , pharmacology , biochemistry , in vitro , polyethylene glycol , medicine , microbiology and biotechnology , finance , economics , biology , oceanography , geology
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.
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