Open AccessDetermining the Pharmacokinetics and Long-Term Biodistribution of SiO2 Nanoparticles In Vivo Using Accelerator Mass Spectrometry
Author(s) -
Michael Malfatti,
Heather A. Palko,
Edward A. Kuhn,
Kenneth W. Turteltaub
Publication year - 2012
Publication title -
nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/nl302412f
Subject(s) - biodistribution , mass spectrometry , pharmacokinetics , nanoparticle , accelerator mass spectrometry , radiochemistry , chemistry , in vivo , materials science , nanotechnology , analytical chemistry (journal) , chromatography , pharmacology , in vitro , medicine , biochemistry , microbiology and biotechnology , biology
Biodistribution is an important factor in better understanding silica dioxide nanoparticle (SiNP) safety. Currently, comprehensive studies on biodistribution are lacking, most likely due to the lack of suitable analytical methods. Accelerator mass spectrometry was used to investigate the relationship between administered dose, pharmacokinetics (PK), and long-term biodistribution of (14)C-SiNPs in vivo. PK analysis showed that SiNPs were rapidly cleared from the central compartment, were distributed to tissues of the reticuloendothelial system, and persisted in the tissue over the 8 week time course, raising questions about the potential for bioaccumulation and associated long-term effects.