Autoassembly Protein Arrays for Analyzing Antibody Cross-Reactivity | Zendy

Richard S. Gaster | Zendy; Drew A. Hall | Zendy; Shan X. Wang | Zendy

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Autoassembly Protein Arrays for Analyzing Antibody Cross-Reactivity

Author(s) -

Richard S. Gaster,

Drew A. Hall,

Shan X. Wang

Publication year - 2010

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl1026056

Subject(s) - nanosensor , cross reactivity , homogeneous , antibody , reactivity (psychology) , nanoparticle , protein array analysis , nanotechnology , chemistry , computational biology , materials science , cross reactions , biology , physics , immunology , medicine , biochemistry , dna microarray , alternative medicine , gene expression , pathology , gene , thermodynamics

We report an autoassembly protein array capable of rapidly screening for aberrant antibody-antigen binding events. Our technique combines magnetic nanoparticle technology with proximity-based, magnetically responsive nanosensors for rapid (under 15 min) and high-density screening of antibody cross-reactivity at sensitivities down to 50 fM in a homogeneous assay. This method will enable the identification of the precise cause of aberrant or cross-reactive binding events in an easy-to-use, rapid, and high-throughput manner.

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