Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond | Zendy

Rochelle R. Arvizo | Zendy; Oscar R. Miranda | Zendy; Michael A. Thompson | Zendy; Christina M. Pabelick | Zendy; Resham Bhattacharya | Zendy; J. David Robertson | Zendy; Vincent M. Rotello | Zendy; Y. S. Prakash | Zendy; Priyabrata Mukherjee | Zendy

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Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond

Author(s) -

Rochelle R. Arvizo,

Oscar R. Miranda,

Michael A. Thompson,

Christina M. Pabelick,

Resham Bhattacharya,

J. David Robertson,

Vincent M. Rotello,

Y. S. Prakash,

Priyabrata Mukherjee

Publication year - 2010

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl101140t

Subject(s) - intracellular , nanoparticle , biophysics , colloidal gold , cell membrane , membrane , nanotechnology , surface charge , cell , chemistry , materials science , biochemistry , biology

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

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