Electronic Signatures of all Four DNA Nucleosides in a Tunneling Gap | Zendy

Shuai Chang | Zendy; Shuo Huang | Zendy; Jin He | Zendy; Feng Liang | Zendy; Peiming Zhang | Zendy; Shengqing Li | Zendy; Xiang Chen | Zendy; Otto F. Sankey | Zendy; Stuart Lindsay | Zendy

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Electronic Signatures of all Four DNA Nucleosides in a Tunneling Gap

Author(s) -

Shuai Chang,

Shuo Huang,

Jin He,

Feng Liang,

Peiming Zhang,

Shengqing Li,

Xiang Chen,

Otto F. Sankey,

Stuart Lindsay

Publication year - 2010

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl1001185

Subject(s) - deoxyadenosine , quantum tunnelling , millisecond , chemistry , deoxyguanosine , electrode , chemical physics , hydrogen bond , dna , reagent , electron , molecular physics , photochemistry , molecule , optoelectronics , materials science , organic chemistry , physics , biochemistry , astronomy , quantum mechanics

Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.

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