Open AccessWide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers
Author(s) -
Pascale R. Leroueil,
Stephanie A. Berry,
Kristen Duthie,
Gang Han,
Vincent M. Rotello,
Daniel Q. McNerny,
James R. Baker,
Bradford G. Orr,
Mark M. Banaszak Holl
Publication year - 2008
Publication title -
nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/nl0722929
Subject(s) - cationic polymerization , lipid bilayer , nanoparticle , nanotechnology , chemistry , materials science , chemical engineering , biophysics , membrane , polymer chemistry , biochemistry , biology , engineering
Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating peptide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH2, SiO2-NH2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.
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