Composite Organic−Inorganic Nanoparticles as Raman Labels for Tissue Analysis | Zendy

Lei Sun | Zendy; KungBin Sung | Zendy; Claire Dentinger | Zendy; Barry R. Lutz | Zendy; Lienchi Nguyen | Zendy; Jingwu Zhang | Zendy; Haoyu Qin | Zendy; Mineo Yamakawa | Zendy; Manqiu Cao | Zendy; Lu Yu | Zendy; AJ Chmura | Zendy; Jing Zhu | Zendy; Xing Su | Zendy; Andrew A. Berlin | Zendy; Selena Chan | Zendy; Beatrice S. Knudsen | Zendy

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Composite Organic−Inorganic Nanoparticles as Raman Labels for Tissue Analysis

Author(s) -

Lei Sun,

KungBin Sung,

Claire Dentinger,

Barry R. Lutz,

Lienchi Nguyen,

Jingwu Zhang,

Haoyu Qin,

Mineo Yamakawa,

Manqiu Cao,

Lu Yu,

AJ Chmura,

Jing Zhu,

Xing Su,

Andrew A. Berlin,

Selena Chan,

Beatrice S. Knudsen

Publication year - 2007

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl062453t

Subject(s) - biomolecule , analyte , nanoparticle , composite number , raman spectroscopy , nanotechnology , materials science , chemistry , chromatography , composite material , optics , physics

Composite organic-inorganic nanoparticles (COINs) are novel optical labels for detection of biomolecules. We have previously developed methods to encapsulate COINs and to functionalize them with antibodies. Here we report the first steps toward application of COINs to the detection of proteins in human tissues. Two analytes, PSA and CK18, are detected simultaneously using two different COINs in a direct binding assay, and two different COINs are shown to simultaneously label PSA in tissue samples.

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